Institute of Medical Statistics, Informatics and Epidemiology, University Hospital Cologne, Cologne, Germany.
Curr Opin Allergy Clin Immunol. 2010 Jun;10(3):206-13. doi: 10.1097/ACI.0b013e32833903a6.
The purpose of this review is to describe the impact that exposure to intermittent hypoxic training (IHT) could have on bronchial asthma and chronic obstructive pulmonary disease (COPD). This is of particular interest, as an increasing number of patients suffer from severe symptoms of bronchial asthma and COPD and desire more effective and efficient treatment options with fewer side effects.
Exposure to IHT has been shown to raise baroreflex sensitivity to normal levels and to selectively increase hypercapnic ventilatory response, total exercise time, total haemoglobin mass, and lung diffusion capacity for carbon monoxide in COPD patients. However, evidence proving that IHT leads to health benefit effects in bronchial asthma patients has not been produced by recent literature.
Recent research outlines the value of IHT as a therapeutic strategy for the treatment of COPD patients, leading to more efficient ventilation. Additionally, IHT might represent an attractive method to complement the known beneficial effects of exercise training and to rebalance early autonomic dysfunction in COPD patients. Future research examining the potential risks and benefits of IHT could pave the way for the development of new therapeutic approaches for patients suffering from bronchial asthma and COPD.
本综述旨在描述间歇性低氧训练（IHT）对支气管哮喘和慢性阻塞性肺疾病（COPD）的影响。这是非常重要的，因为越来越多的患者患有严重的支气管哮喘和 COPD 症状，他们希望有更有效和高效的治疗方法，同时副作用更少。
暴露于 IHT 已被证明可提高血压反射敏感性至正常水平，并选择性地增加 COPD 患者的高碳酸血症通气反应、总运动时间、总血红蛋白质量和一氧化碳肺弥散量。然而，最近的文献并没有证明 IHT 导致支气管哮喘患者的健康获益。
最近的研究概述了 IHT 作为 COPD 患者治疗策略的价值，可导致更有效的通气。此外，IHT 可能代表一种有吸引力的方法，以补充运动训练的已知有益效果，并重新平衡 COPD 患者早期的自主神经功能障碍。未来研究检查 IHT 的潜在风险和益处可能为患有支气管哮喘和 COPD 的患者开发新的治疗方法铺平道路。
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