Stanford University, Stanford, California, USA.
Curr Opin Anaesthesiol. 2010 Jun;23(3):411-6. doi: 10.1097/ACO.0b013e32833953fb.
Patients with pulmonary hypertension who undergo anesthesia and surgery have high morbidity and mortality. Recent advances in our understanding of pulmonary hypertension and its therapy provide an opportunity to improve outcomes.
Pulmonary hypertension can be classified into several subtypes, each with its own causes, pathophysiology, and therapy. Echocardiography remains a critical aspect of the evaluation of patients with pulmonary hypertension, but estimation of right ventricular systolic pressure is often inaccurate. Inhaled vasodilators can produce selective and potent pulmonary vasodilation.
The cause of pulmonary hypertension should be defined in perioperative patients with pulmonary hypertension, and therapy should be optimized prior to anesthesia. Pulmonary artery catheterization may be required to confirm the presence of pulmonary hypertension and its severity. The focus of anesthetic management is to maintain right ventricular cardiac output and avoid systemic hypotension. Inhaled vasodilators such as nitric oxide and prostacyclin can be life-saving when perioperative right heart failure occurs due to exacerbation of pulmonary hypertension.
患有肺动脉高压的患者在接受麻醉和手术时,发病率和死亡率都很高。我们对肺动脉高压及其治疗的理解的最新进展为改善预后提供了机会。
肺动脉高压可分为几种亚型,每种亚型都有其特定的病因、病理生理学和治疗方法。超声心动图仍然是肺动脉高压患者评估的关键方面,但右心室收缩压的估计往往不准确。吸入性血管扩张剂可产生选择性和有效的肺血管扩张作用。
患有肺动脉高压的围手术期患者应明确肺动脉高压的病因,并在麻醉前优化治疗。可能需要肺动脉导管检查来确认肺动脉高压的存在及其严重程度。麻醉管理的重点是维持右心室心输出量,避免全身低血压。当由于肺动脉高压加重导致围手术期右心衰竭发生时,吸入性血管扩张剂如一氧化氮和前列环素可以挽救生命。