Xu L, Chen J J
Department of Physiology, Qingdao Medical College.
Sheng Li Xue Bao. 1991 Feb;43(1):84-8.
The effect of neurotensin (NT) was studied by method of radioimmunoassay, microinjection and spectrophotofluorometry in locus coeruleus of rat on vagus-pressor response. The results were as follows: (1) The contents of neurotensin immune reactivity (NT-IR) in the nucleus of the tractus solitarius (NTS), LC and hypothalamus were significantly increased by stimulation of the central end of vagi (P less than 0.05); (2) The vagus-pressor response was significantly weakened by NT injection into the LC (P less than 0.01), being dose-dependent; (3) The vagus-pressor response was significantly potentiated by antineurotensin serum injected into the LC (P less than 0.01); (4) The content of noradrenaline (NA) was increased by stimulation of the central end of vagi after microinjection of NT into the LC. The results indicate that endogenous and exogenous NT in the locus coeruleus of the rat may modulate vagus-pressor response, possibly mediated by the increase in the content of NA in LC.
采用放射免疫测定法、微量注射法和分光荧光测定法，研究了神经降压素（NT）对大鼠蓝斑迷走加压反应的影响。结果如下：（1）刺激迷走神经中枢端后，孤束核（NTS）、蓝斑（LC）和下丘脑的神经降压素免疫反应性（NT-IR）含量显著增加（P<0.05）；（2）向蓝斑注射NT可显著减弱迷走加压反应（P<0.01），且呈剂量依赖性；（3）向蓝斑注射抗神经降压素血清可显著增强迷走加压反应（P<0.01）；（4）向蓝斑微量注射NT后，刺激迷走神经中枢端可使去甲肾上腺素（NA）含量增加。结果表明，大鼠蓝斑内的内源性和外源性NT可能通过增加蓝斑内NA含量介导，调节迷走加压反应。
