Wang Y, Gu Y, Lu Y, Li L, Tan L
Department of Physiology, Beijing Medical University.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):337-41.
Substance P(SP)-immunoreactive cell bodies, axon terminals and SP receptors were widely scattered in most pressor areas. Lateral hypothalamus (LH) contains SPergic neurons; and SPergic fibers-SP receptors are present in LH projection areas; hence the role of SP in LH-pressor response was studied. The results showed that: (1) microinjection of glutamate into the lateral hypothalamus-perifornical region (LH/PF) or SP into LH projection areas: the locus coeruleus (LC), periaqueductal gray matter (PAG) or nucleus parabrachialis (NPB), respectively, all could induce pressor response; (2) preinjection of DPDPDT (a substance P antagonist) into the LC, PAG (but not NPB) reduced the LH/PF pressor response; (3) intra-RVL (rostral ventrolateral medulla) injection of phentolamine, propranolol or atropine also markedly attenuated the LH/PF pressor response. Taken together with our previous findings that alpha-, beta- and M-receptors in the RVL mediated the pressor response to excitation of LC, and alpha-, beta-receptors mediated the PAG-pressor response, it is suggested that the LH/PF pressor response may be brought about via the activation of LC- and PAG-RVL systems by SPergic fibers from the LH/PF.
P物质（SP）免疫反应性细胞体、轴突终末和SP受体广泛分布于大多数升压区。下丘脑外侧区（LH）含有P物质能神经元；且LH投射区存在P物质能纤维和SP受体；因此研究了SP在LH升压反应中的作用。结果表明：（1）分别向外侧下丘脑-穹窿周区（LH/PF）微量注射谷氨酸或向LH投射区蓝斑（LC）、导水管周围灰质（PAG）或臂旁核（NPB）微量注射SP，均可诱导升压反应；（2）预先向LC、PAG（而非NPB）注射DPDPDT（一种P物质拮抗剂）可降低LH/PF升压反应；（3）向延髓头端腹外侧区（RVL）内注射酚妥拉明、普萘洛尔或阿托品也可显著减弱LH/PF升压反应。结合我们之前的研究结果，即RVL中的α、β和M受体介导了对LC兴奋的升压反应，且α、β受体介导了PAG升压反应，提示LH/PF升压反应可能是由LH/PF的P物质能纤维激活LC和PAG-RVL系统所致。
