[31P磁共振波谱法评估白血病肝脏浸润中的生化代谢物]

[Evaluation of biochemical metabolites by 31P MR spectroscopy in leukemic infiltration of liver].

作者信息

Sun Jian-zhong, Wang Zhi-kang, Yu Ri-sheng, Huang Lian-sheng, Xu Xiu-fang, Zhang Min-ming

机构信息

Department of Radiology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Mar;39(2):150-6. doi: 10.3785/j.issn.1008-9292.2010.02.007.

DOI:10.3785/j.issn.1008-9292.2010.02.007

PMID:20387242

Abstract

OBJECTIVE

To evaluate the changes of phosphorus metabolites in leukemic infiltration of liver (LIL) with two-dimensional chemical shift imaging(2D CSI)(31)phosphorus MR spectroscopy ((31)P MRS).

METHODS

Fifteen patients with LIL and 12 healthy subjects (control group) were scanned with liver 2D CSI(31)P MRS by a 1.5T MR Scanner(Sonata, Siemens Corporation). Relative quantification of phosphorus metabolites including phosphomonoesters (PME), inorganic phosphate (Pi), phosphodiesters (PDE) and beta-adenosine- triphosphate (beta-ATP) were detected and after calibrated with model factor, the ratios of PME/PDE, PME/(PME+PDE), PME/ATP, PDE/ATP and Pi/ATP were analyzed.

RESULTS

Compared with control group, the PME value, PME/PDE ratio, PME/(PME+PDE) ratio and PME/ATP ratio were increased in LIL group (1.992 +/-0.876 Compared with 1.167 +/-0.427, P <0.05), (0.551 +/-0.339 Compared with 0.254 +/-0.059,P <0.01), (0.326 +/-0.13 Compared with 0.199 +/-0.049, P <0.01)and (1.402 +/-0.654 Compared with 0.792 +/-0.232, P <0.01) respectively.

CONCLUSION

(31)P MRS examination can be used as a non-invasive procedure to evaluate the changes of phosphorus metabolites of leukemic infiltration of liver. The increase of PME value and its ratios to PDE, ATP and PME+PDE may indicate leukemic infiltration of liver.

摘要

目的

采用二维化学位移成像（2D CSI）磷磁共振波谱（³¹P MRS）评估白血病肝脏浸润（LIL）时磷代谢物的变化。

方法

对15例LIL患者和12名健康受试者（对照组）使用1.5T磁共振扫描仪（西门子公司Sonata）进行肝脏2D CSI³¹P MRS扫描。检测磷单酯（PME）、无机磷酸盐（Pi）、磷二酯（PDE）和β-三磷酸腺苷（β-ATP）等磷代谢物的相对定量，经模型因子校准后，分析PME/PDE、PME/（PME+PDE）、PME/ATP、PDE/ATP和Pi/ATP的比值。

结果

与对照组相比，LIL组的PME值、PME/PDE比值、PME/（PME+PDE）比值和PME/ATP比值均升高（分别为1.992±0.876与1.167±0.427，P<0.05），（0.551±0.339与0.254±0.059，P<0.01），（0.326±0.13与0.199±0.049，P<0.01）和（1.402±0.654与0.792±0.232，P<0.01）。