Tian Man, Zhao De-yu, Wen Guan-yu, Shi Sheng-yun
Department of Respiratory Medicine, the Affiliated Nanjing Children's Hospital of NJMU, Nanjing 210008, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Oct;23(5):371-4.
To observe the correlation factor about early-life RSV bronchiolitis and sequential recurrent wheezing for two years.
Follow up the RSV bronchiolitis patients for two years in order to analyze the occurrence of wheezing post-bronchiolitis. Single and multiple logistic regression analysis were used to determined the risk factors such as individual atopy history and familial atopy history, pet feeding, breast milk, secondhand smoke for RSV bronchiolitis and subsequent wheezing.
(1) Not breast feeding, exposure to cigarette smoke and the deficiency of VitA, D were the significant risk factors contributed to the RSV branchiolitis. (2) Exposure to cigarette smoke, the deficiency of VitA, D, the personal history of atopy and the family history of atopy were the significant risk factors contributed to the post-bronchiolitis wheezing in children. (3) Those patients who eosinophilia, high serum IgE, RANTES and decreased TH1 to TH2 Ratio were more likely to have wheezing after RSV bronchiolitis.
(1) Not breast feeding, exposure to cigarette smoke and the deficiency of VitA, D were the significant risk factors contributed to the RSV bronchiolitis. (2) Exposure to cigarette smoke, the deficiency of VitA, D, the personal history of atopy and the family history of atopy were the significant risk factors contributed to the post-bronchiolitis wheezing in children.
观察生命早期呼吸道合胞病毒（RSV）细支气管炎与后续两年反复喘息的相关因素。
对RSV细支气管炎患者进行两年随访，以分析细支气管炎后喘息的发生情况。采用单因素和多因素逻辑回归分析确定个体过敏史、家族过敏史、饲养宠物、母乳喂养、二手烟暴露等RSV细支气管炎及后续喘息的危险因素。
（1）非母乳喂养、接触香烟烟雾以及维生素A、D缺乏是导致RSV细支气管炎的重要危险因素。（2）接触香烟烟雾、维生素A、D缺乏、个人过敏史和家族过敏史是导致儿童细支气管炎后喘息的重要危险因素。（3）嗜酸性粒细胞增多、血清IgE升高、RANTES升高以及TH1/TH2比值降低的患者在RSV细支气管炎后更易发生喘息。
（1）非母乳喂养、接触香烟烟雾以及维生素A、D缺乏是导致RSV细支气管炎的重要危险因素。（2）接触香烟烟雾、维生素A、D缺乏、个人过敏史和家族过敏史是导致儿童细支气管炎后喘息的重要危险因素。
