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[甲磺酸伊马替尼治疗的一种罕见并发症:药物性肺炎]

[A rare complication of imatinib mesylate therapy: drug-induced pneumonitis].

作者信息

Stakhina O V, Turkina A G, Kostina I E, Kochkareva Iu B

出版信息

Ter Arkh. 2010;82(2):59-61.

Abstract

The use of imatinib mesylate (Glivec) (Novartis Pharma AG, Switzerland) that is the drug of choice in treating patients with chronic myeloid leukemia (CML) has increased 7-year survival and improved the prognosis of the disease. The drug is generally tolerated well; the proportion of patients in whom imatinib treatment results in the development of toxic complications is small. Drug-induced interstitial pneumonitis associated with imatinib therapy is a rare complication that requires timely differential diagnosis, discontinuation of an inductor (imatinib), and altered further treatment policy.

摘要

甲磺酸伊马替尼(格列卫)(瑞士诺华制药公司)是治疗慢性粒细胞白血病(CML)患者的首选药物,它提高了患者7年生存率并改善了疾病预后。该药物总体耐受性良好;伊马替尼治疗导致毒性并发症的患者比例较小。与伊马替尼治疗相关的药物性间质性肺炎是一种罕见的并发症,需要及时进行鉴别诊断、停用诱导剂(伊马替尼)并改变进一步的治疗策略。

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