高选择性叶立德引发的迈克尔加成/环化反应合成环己二烯环氧化物和乙烯基环丙烷衍生物。

Highly selective ylide-initiated Michael addition/cyclization reaction for synthesis of cyclohexadiene epoxide and vinylcyclopropane derivatives.

机构信息

Key Laboratory of Organic Synthesis, Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, PR China.

出版信息

J Org Chem. 2010 May 21;75(10):3454-7. doi: 10.1021/jo100306z.

DOI:10.1021/jo100306z

PMID:20387850

Abstract

On the basis of the reactions of camphor-derived sulfur ylide with alpha,beta-unsaturated ketone, highly efficient and selective synthesis of optically active cyclohexadiene epoxides and vinylcyclopropanes with excellent diastereoselectivities, moderate to high enantioselectivities, and yields has been achieved.

摘要

基于莰烯衍生的硫叶立德与α,β-不饱和酮的反应，实现了具有优异的非对映选择性、中等至高的对映选择性和产率的光学活性环己二烯环氧化物和乙烯基环丙烷的高效和选择性合成。