超声对非水溶剂中脂肪酶催化的芒果苷区域选择性酰化反应的影响。
The effect of ultrasound on lipase-catalyzed regioselective acylation of mangiferin in non-aqueous solvents.
作者信息
Wang Zhi, Wang Ren, Tian Jin, Zhao Bo, Wei Xiao-Fei, Su Ya-Lun, Li Chun-Yuan, Cao Shu-Gui, Ji Teng-Fei, Wang Lei
机构信息
Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, China.
出版信息
J Asian Nat Prod Res. 2010 Jan;12(1):56-63. doi: 10.1080/10286020903431080.
A simple and efficient method for regioselective acylation of mangiferin catalyzed by lipase under ultrasound irradiation is reported. Compared with the conventional methods, its main advantages are shorter reaction time and higher yields. The optimum conditions were screened out. Under the optimal conditions (lipase: PCL, acyl donor: vinyl acetate; reaction solvent: DMSO, reaction temperature: 45 degrees C, ultrasonic power: 200 W; substrate ratio: acyl donor/mangiferin 6/1, enzyme loading: 6 mg/ml), the regioselective acylation yield was up to 84%.
报道了一种在超声辐照下脂肪酶催化芒果苷区域选择性酰化的简单高效方法。与传统方法相比，其主要优点是反应时间更短、产率更高。筛选出了最佳条件。在最佳条件下（脂肪酶：PCL，酰基供体：乙酸乙烯酯；反应溶剂：DMSO，反应温度：45℃，超声功率：200W；底物比例：酰基供体/芒果苷6/1，酶负载量：6mg/ml），区域选择性酰化产率高达84%。
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