Estrada-Villaseñor Eréndira, Rico-Martínez Genaro, Linares-Gonzalez Luis Miguel
Department of Pathology and Bone Tumors Service, National Institute of Rehabilitation, Mexico City, Mexico.
Acta Cytol. 2010 Mar-Apr;54(2):217-20. doi: 10.1159/000325014.
Dedifferentiated chondrosarcomas account for approximately 10% of all chondrosarcomas. There are few reports that describe the cytologic findings in dedifferentiated chondrosarcomas. In all these cases it was only present in the smears as a high grade sarcoma component.
A 58-year-old man with a bone lesion in the right acetabular zone was admitted to the hospital. The clinical diagnosis was chondrosarcoma. A fine needle aspiration biopsy was performed. The smears of the sample had different characteristics in composition. Some slides had mostly abundant chondroid matrix with low to moderate cellularity. Other slides were cellular and contained mainly pleomorphic, spindled-shaped cells. The typical appearance of dedifferentiated chondrosarcoma was present in some slides that showed focal zones with chondroid matrix adjacent to or surrounded by pleomorphic spindled cells. The composition of the surgical specimen (slightly greater cartilaginous component than the sarcomatous one) allowed us to make a straightforward diagnosis of dedifferentiated chondrosarcoma.
This is the first report that describes the presence of both components, high and low grade, by fine needle aspiration biopsy in dedifferentiated chondrosarcoma.
去分化软骨肉瘤约占所有软骨肉瘤的10%。很少有报告描述去分化软骨肉瘤的细胞学表现。在所有这些病例中，它仅在涂片上作为高级别肉瘤成分出现。
一名58岁男性因右髋臼区骨病变入院。临床诊断为软骨肉瘤。进行了细针穿刺活检。样本涂片在成分上有不同特征。一些玻片主要有丰富的软骨样基质，细胞数量少至中等。其他玻片细胞较多，主要含有多形性梭形细胞。去分化软骨肉瘤的典型表现出现在一些玻片上，显示出有软骨样基质的局灶区域，其邻近或被多形性梭形细胞包围。手术标本的成分（软骨成分略多于肉瘤成分）使我们能够直接诊断为去分化软骨肉瘤。
这是第一份通过细针穿刺活检描述去分化软骨肉瘤中高级别和低级别两种成分均存在的报告。
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