细胞凋亡：整合素在清除过程中的保守作用。

Apoptosis: conserved roles for integrins in clearance.

机构信息

UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

出版信息

Curr Biol. 2010 Apr 13;20(7):R324-7. doi: 10.1016/j.cub.2010.02.043.

DOI:10.1016/j.cub.2010.02.043

PMID:20392425

Abstract

A recent study shows that one of the two known Caenorhabditis elegans homologs of the mammalian integrin alpha subunit plays an essential role in the clearance of apoptotic cells - efferocytosis - during nematode development. These new findings reveal that integrins have evolutionarily conserved functions in efferocytosis in metazoans.

摘要

最近的一项研究表明，两种已知的秀丽隐杆线虫整联蛋白α亚基同源物之一在秀丽隐杆线虫发育过程中清除凋亡细胞（吞噬作用）的过程中发挥着重要作用。这些新发现揭示了整联蛋白在后生动物的吞噬作用中具有进化保守的功能。