Gregory J W, Greene S A, Jung R T, Scrimgeour C M, Rennie M J
Department of Child Health, University of Dundee.
Arch Dis Child. 1991 May;66(5):598-602. doi: 10.1136/adc.66.5.598.
Changes in body composition and energy expenditure were assessed in 15 children after six weeks of human growth hormone (hGH) treatment. Body composition measurements were made by stable isotope labelled water (H2(18)O) dilution, bioelectrical impedance, and skinfold thickness techniques. Energy expenditure was assessed both by indirect ventilated hood calorimetry (resting energy expenditure) and the stable isotope doubly labelled water (2H2(18)O) technique (free living daily total energy expenditure). Mean increases in weight of 0.96 kg and fat free mass of 1.37 kg and a mean decrease in fat mass of 0.41 kg were observed. Significant increases both in resting energy expenditure and free living daily energy expenditure were detected. Absolute changes in fat mass and resting energy expenditure were correlated. The data suggest (i) that the increase in the fat free mass is the most significant early clinical measure of hGH response and (ii) that hGH increases the metabolic activity of the fat free mass. Monitoring such changes may be predictive of the efficacy of hGH in promoting growth.
在15名儿童接受六周人生长激素（hGH）治疗后，对其身体成分和能量消耗的变化进行了评估。通过稳定同位素标记水（H2(18)O）稀释法、生物电阻抗法和皮褶厚度技术进行身体成分测量。通过间接通气罩热量测定法（静息能量消耗）和稳定同位素双标记水（2H2(18)O）技术（自由生活每日总能量消耗）评估能量消耗。观察到体重平均增加0.96千克，去脂体重平均增加1.37千克，脂肪量平均减少0.41千克。检测到静息能量消耗和自由生活每日能量消耗均显著增加。脂肪量和静息能量消耗的绝对变化具有相关性。数据表明：（i）去脂体重的增加是hGH反应最显著的早期临床指标；（ii）hGH增加了去脂体重的代谢活性。监测这些变化可能有助于预测hGH促进生长的疗效。
