Simpson M A, Young-Fadok T M, Madras P N, Freeman R B, Dempsey R A, Shaffer D, Lewis D, Jenkins R L, Monaco A P
Division of Organ Transplantation, New England Deaconess Hospital, Boston, Mass.
Arch Surg. 1991 Jun;126(6):717-9; discussion 719-20. doi: 10.1001/archsurg.1991.01410300063009.
Previous studies of renal transplant recipients have demonstrated that allograft rejection is accompanied by an increase in plasma and urinary levels of interleukin 2 and its soluble receptor before the development of clinical symptoms. After measuring interleukin 2 and interleukin 2 receptor levels in the plasma, bile, and urine of liver transplant recipients, we found that rejection is preceded by elevation of plasma and biliary levels of both substances, that cyclosporine toxicity did not affect either of these levels, and that urinary levels of the substances are unaffected in either condition. Levels of interleukin 2 and interleukin 2 receptors increased in bile earlier than in plasma, and interleukin 2 levels did not overlap among stable patients and those experiencing rejection, whereas levels of interleukin 2 receptors did. Serial measurements of interleukin 2 levels, particularly in the product of the transplanted organ, provide a reliable assessment of the immunologic status of the allograft.
先前对肾移植受者的研究表明，在临床症状出现之前，同种异体移植排斥反应伴随着血浆和尿液中白细胞介素2及其可溶性受体水平的升高。在测量肝移植受者的血浆、胆汁和尿液中的白细胞介素2和白细胞介素2受体水平后，我们发现排斥反应之前这两种物质的血浆和胆汁水平会升高，环孢素毒性不会影响这两种水平中的任何一种，并且在这两种情况下尿液中这些物质的水平均不受影响。白细胞介素2和白细胞介素2受体水平在胆汁中升高的时间早于血浆，白细胞介素2水平在稳定患者和发生排斥反应的患者之间没有重叠，而白细胞介素2受体水平有重叠。对白细胞介素2水平进行连续测量，特别是在移植器官的产物中进行测量，可对同种异体移植的免疫状态提供可靠的评估。
