人参皂苷Rg1经鼻给药的可行性研究
[Feasibility study of ginsenoside Rg1 administrated via intranasal route].
作者信息
Chen Xinmei
机构信息
Shan Dong Traditional Chinese Medical Uinversity, Jinan 250355, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(2):229-31. doi: 10.4268/cjcmm20100226.
OBJECTIVE
To study the feasibility of ginsenoside Rg1 administrated from nasal route.
METHOD
The safty of ginsenoside Rg1 was evaluated by testing cilia movement of the in situ toad palate model. The stability of ginsenoside Rg1 to nasal enzymes and pH was evaluated by HPLC method. Nasal circulatory perfusion test in vivo had been empolyed to investigated absorption effect of ginsenoside Rg1 from nasal mucosa.
RESULT
Ginsenoside Rg1 was safe to the cilia movement. Meanwhile, it's stable to nasal enzymes and pH. Ginsenoside Rg1 can be absorbed from nasal route.
CONCLUSION
It's feasible to administrate ginsenoside Rg1 from nasal route.
目的
研究人参皂苷Rg1经鼻腔给药的可行性。
方法
通过检测原位蟾蜍腭模型的纤毛运动来评估人参皂苷Rg1的安全性。采用高效液相色谱法评估人参皂苷Rg1对鼻腔酶和pH的稳定性。运用体内鼻腔循环灌注试验研究人参皂苷Rg1从鼻黏膜的吸收效果。
结果
人参皂苷Rg1对纤毛运动安全。同时，它对鼻腔酶和pH稳定。人参皂苷Rg1可经鼻腔吸收。
结论
人参皂苷Rg1经鼻腔给药是可行的。
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