拉普吲哚类化合物：来自拟南芥 Raputia 的新型环戊基双吲哚生物碱。

The raputindoles: novel cyclopentyl bisindole alkaloids from Raputia simulans.

机构信息

Division of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Panepistimioupoli Zografou, Athens, Greece.

出版信息

Org Lett. 2010 May 7;12(9):1908-11. doi: 10.1021/ol100584w.

DOI:10.1021/ol100584w

PMID:20394392

Abstract

A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS. Raputindoles A-D possess a cyclopentyl moiety fused on the benzene part of the indole ring, originating from the combination of prenylated indole monomers.

摘要

从亚马逊植物 Raputia simulans Kallunki（Rutaceae）中分离和结构鉴定出的拉普丁烷 A-D（1-4）建立了一类新型的双吲哚生物碱。通过 NMR 光谱和 APCI（+）HRMS 完成了完整的光谱特征描述。拉普丁烷 A-D 具有一个环戊基部分，与吲哚环的苯部分融合，来源于被prenylated 的吲哚单体的组合。