University Children's Hospital, Tübingen, Germany.
Horm Res Paediatr. 2010;74(1):50-5. doi: 10.1159/000313369. Epub 2010 Apr 15.
BACKGROUND/AIMS: A more advanced bone age (BA) has been reported for the left hand relative to the right hand, while another study has found no such effect. The aim was to study the average difference of automated BoneXpert BA determination (left- vs. right-hand) for normal children, examine the precision of automatic BA and provide a BA reference for normal Caucasian children.
Radiographs of both hands (age range: 2-20 years) were digitised and analysed automatically to determine Greulich-Pyle BA, producing analysis results for 3,374 left-hand and 2,752 right-hand images.
Comparison of left- and right-hand BA showed no average difference (<0.07 years, 95% confidence). The SD of the differences between left and right sides was 0.25 years for boys as well as girls, implying the precision of automated Greulich-Pyle BA determination was 0.18 years or better. Greulich-Pyle BA for boys and girls were on average 0.10 and 0.21 years below the chronological age.
The left and right hand give the same BA on average and the SD between the sides is 0.25 years, indicating an excellent precision of the automated method.
背景/目的：与右手相比，左手的骨龄（BA）通常更为先进，而另一项研究则未发现这种影响。本研究旨在研究正常儿童左手与右手自动 BoneXpert BA 测定（左手与右手）的平均差异，检验自动 BA 的精确性，并为正常白种儿童提供 BA 参考值。
对手部的 X 光片（年龄范围：2-20 岁）进行数字化并自动分析，以确定 Greulich-Pyle BA，为 3374 张左手图像和 2752 张右手图像提供分析结果。
比较左手和右手的 BA 显示没有平均差异（<0.07 岁，95%置信区间）。男孩和女孩左右两侧差值的标准差均为 0.25 岁，这意味着自动 Greulich-Pyle BA 测定的精确性在 0.18 岁或更好。男孩和女孩的 Greulich-Pyle BA 平均比实际年龄低 0.10 岁和 0.21 岁。
左手和右手的 BA 平均值相同，两侧之间的标准差为 0.25 岁，表明自动方法的精度非常好。
