Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, UAE.
Mediators Inflamm. 2010;2010:823821. doi: 10.1155/2010/823821. Epub 2010 Apr 12.
NF-kappaB comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-kappaB in inflammation and atherosclerosis and the regulation of the NF-kappaB signaling pathway are summarized. The structure, function, and regulation of the NF-kappaB inhibitors, IkappaBalpha and IkappaBbeta, are reviewed. The regulation of NF-kappaB activity by glucocorticoid receptor (GR) signaling and IkappaBalpha sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-kappaB transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-kappaB via physical interaction with IkappaBalpha and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IkappaBalpha-interacting proteins play in NF-kappaB signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.
NF-κB 是一组转录因子，它们在各种炎症过程中起着至关重要的作用。本文总结了 NF-κB 在炎症和动脉粥样硬化中的作用以及 NF-κB 信号通路的调节。综述了 NF-κB 抑制剂 IkappaBalpha 和 IkappaBbeta 的结构、功能和调节。还讨论了糖皮质激素受体 (GR) 信号和 IkappaBalpha 泛素化对 NF-κB 活性的调节。本文重点介绍了最近报道的脂肪细胞增强结合蛋白 1 (AEBP1) 在巨噬细胞中对 NF-κB 转录活性的调节功能，AEBP1 通过与 IkappaBalpha 的物理相互作用以及作为炎症的关键介质，表现为 NF-κB 的有效调节剂。最后，我们总结了最近鉴定的与 IkappaBalpha 相互作用的蛋白质在 NF-κB 信号中的调节作用。基于其在巨噬细胞中的促炎作用，AEBP1有望成为治疗各种炎症性疾病的治疗靶点。
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