Department of Medicinal Chemistry in the College of Pharmacy, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Chembiochem. 2010 May 3;11(7):880-902. doi: 10.1002/cbic.200900779.
Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.
尽管氨基糖苷类抗生素已经使用了几十年，但由于其固有的毒性和对这些化合物的耐药性，它们的应用受到了阻碍。这些问题似乎使曾经的一线抗菌药物沦为了“过气”药物。然而，最近的进展表明，新型氨基糖苷类抗生素具有克服耐药性的潜力，甚至可以用于治疗 HIV-1 和人类遗传疾病，同时降低毒性。氨基糖苷类抗生素的时代并未结束，相反，研究人员所面临的挑战促使他们发挥创造力，并改变了我们对这类化合物的看法，迎来了新的发展。
