There is growing interest in examining the extent to which evidence-based interventions, found to be efficacious for majority populations, are effective for low-income, ethnically diverse populations. Yet limited attention has been devoted to documenting the specific steps taken in adapting these interventions to meet the needs of the target ethnic population. This article describes the cultural adaptation of an evidence-based cognitive-behavioral therapy intervention to prevent perinatal depression in 2 different Latina immigrant communities using a 5-step iterative process: (a) identify need; (b) gather information; (c) design adaptation; (d) implement, evaluate, and refine adaptation; and (e) replicate and disseminate. Appropriate adaptations of evidence-based interventions have the potential to reduce disparities in utilization and outcomes for high-risk populations. Researchers should document their efforts to transform services for low-income, ethnically diverse populations.