Newlon P G, Goldberg S J, Hayes R L
Department of Neurosurgery, Eastern Virginia Medical School, Norfolk 23507.
Brain Res. 1991 Mar 29;544(2):320-4. doi: 10.1016/0006-8993(91)90072-4.
The effects of high-frequency stimulation (HFS) of the medial septum/diagonal band (MSDB) on long-term potentiation (LTP) of CA1 extracellular field potentials were assessed in anesthetized rats. Ten rats received HFS of the Schaffer collateral pathway alone, and 10 received MSDB HFS 10 min prior to hippocampal HFS. Septal HFS suppressed LTP development assessed by change in population spike (PS) amplitude 60 min after hippocampal HFS (ANOVA, P less than 0.03). Septal inhibition of LTP development was most prominent when septal HFS had little direct effect on the CA1 PS. These results provide a novel demonstration of the functional heterogeneity of septohippocampal pathways and in vivo modulation of hippocampal LTP by HFS of natural afferent inputs.
在麻醉大鼠中评估了内侧隔区/斜角带（MSDB）高频刺激（HFS）对CA1细胞外场电位长时程增强（LTP）的影响。10只大鼠仅接受了海马旁回通路的HFS，另外10只在海马HFS前10分钟接受了MSDB HFS。隔区HFS抑制了海马HFS 60分钟后通过群体峰电位（PS）幅度变化评估的LTP发展（方差分析，P小于0.03）。当隔区HFS对CA1 PS几乎没有直接影响时，隔区对LTP发展的抑制最为显著。这些结果首次证明了隔海马通路的功能异质性以及自然传入输入的HFS对海马LTP的体内调节作用。
