Overview and historical perspective of four papers presented on research related to the endogenous opioid system.
作者信息
Kreek Mary Jeanne
机构信息
The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA.
出版信息
Drug Alcohol Depend. 2010 May 1;108(3):195-9. doi: 10.1016/j.drugalcdep.2010.03.003. Epub 2010 Apr 18.
Abstract
摘要
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本文引用的文献
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Addict Biol. 1997 Jul;2(3):303-8. doi: 10.1080/13556219772598.
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Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions.阿片类药物与成瘾：问题与寻求解决办法的研究方向。
Drug Alcohol Depend. 2010 May 1;108(3):156-65. doi: 10.1016/j.drugalcdep.2010.01.001. Epub 2010 Feb 25.
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OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.OPRM1 SNP（A118G）：在疾病发展、治疗反应和动物模型中的作用。
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The endogenous opioid system: a common substrate in drug addiction.内源性阿片系统：药物成瘾的共同基础。
Drug Alcohol Depend. 2010 May 1;108(3):183-94. doi: 10.1016/j.drugalcdep.2009.10.011. Epub 2009 Nov 28.
6
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.OPRM1（A118G）基因多态性的小鼠模型对药物介导的行为具有性别特异性影响。
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10847-52. doi: 10.1073/pnas.0901800106. Epub 2009 Jun 15.
7
Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin.通过合成小干扰RNA敲低黑质/腹侧被盖区的μ阿片受体可阻断海洛因的奖赏和运动效应。
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Genetic susceptibility to heroin addiction: a candidate gene association study.海洛因成瘾的遗传易感性：一项候选基因关联研究。
Genes Brain Behav. 2008 Oct;7(7):720-9. doi: 10.1111/j.1601-183X.2008.00410.x. Epub 2008 Jun 2.
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Clin Pharmacol Ther. 2008 Apr;83(4):615-8. doi: 10.1038/clpt.2008.5. Epub 2008 Mar 5.
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