使用 3.0T 与 1.5T 钆喷酸葡胺行全心脏冠状动脉对比增强磁共振血管成像

Contrast-enhanced whole-heart coronary MRA using Gadofosveset 3.0 T versus 1.5 T.

机构信息

Klinikum Grosshadern, Ludwig Maximilians Universität München Marchioninistr., Germany.

出版信息

Acad Radiol. 2010 Jul;17(7):862-70. doi: 10.1016/j.acra.2010.02.009.

DOI:10.1016/j.acra.2010.02.009

PMID:20399687

Abstract

RATIONALE AND OBJECTIVES

To compare contrast-enhanced coronary magnetic resonance angiography (MRA) at 3.0 T with the same technique performed at 1.5 T using the contrast agent gadofosveset.

MATERIALS AND METHODS

In this prospective randomized study, 19 healthy male volunteers (mean age 28 years, mean weight 79.8 kg), after signing informed consents, underwent contrast-enhanced inversion recovery three-dimensional fast low angle shot (FLASH) MRA at 1.5 and at 3.0 T. Prospective electrocardiogram-triggering was combined with adaptive respiratory gating. For contrast-enhanced images, the intravascular contrast agent gadofosveset was used. Acquisition time, signal-to-noise ratio (SNR) of coronary blood, contrast-to-noise ratio (CNR) between coronaries and adjacent myocardium or epicardial fat and image quality were analyzed for statistical differences by using a two-tailed paired-sample t-test. The ratio calculations were based on measurements performed on the raw data and the image quality was blinded and independently evaluated by two experienced radiologists using a five-point scale.

RESULTS

The mean values for the acquisition time were 14.58 +/- 0.1 minutes at 1.5 T and 16.40 +/- 0.2 minutes at 3.0 T. Overall SNR of all evaluated coronary segments proved higher at 3.0 T compared to 1.5 T (74.0 +/- 42.1 at 3.0 T vs. 50.2 +/- 20.2 at 1.5 T, P = .04). Overall CNR between coronaries and myocardium was significantly increased at 3.0 T in comparison to 1.5 T (40.1 +/- 21.9 at 3.0 T vs. 24.4 +/- 17.2 at 1.5 T, P = .01). Between the two methods, no significant difference in overall CNR between coronaries and epicardial fat was observed (P = .08, NS). The 3.0 T MRA demonstrated superior overall image quality with respect to 1.5 T (2.28 +/- 0.71 at 3.0 T vs. 1.92 +/- 0.38 at 1.5T, P = .004).

CONCLUSION

The use of higher field strength, 3.0 T instead of 1.5 T, resulted in similar CNR between coronaries and epicardial fat, higher SNR values and CNR between blood and myocardium, as well as an improved overall image quality, when gadofosveset in combination with electrocardiogram and respiratory triggering for coronary MRA was used.

摘要

背景和目的

本研究旨在比较使用对比剂钆喷酸葡胺（gadofosveset）在 3.0 T 和 1.5 T 磁共振成像（MRI）扫描仪上进行对比增强冠状动脉磁共振血管造影（MRA）的结果。

材料和方法

本前瞻性随机研究纳入了 19 名健康男性志愿者（平均年龄 28 岁，平均体重 79.8kg），在签署知情同意书后，分别在 1.5 T 和 3.0 T 磁共振扫描仪上进行对比增强反转恢复三维快速小角度激发（FLASH）MRA。前瞻性心电图触发与自适应呼吸门控相结合。对于对比增强图像，使用静脉内对比剂钆喷酸葡胺。通过双尾配对样本 t 检验对采集时间、冠状动脉血液的信噪比（SNR）、冠状动脉与邻近心肌或心外膜脂肪之间的对比噪声比（CNR）以及图像质量进行统计学差异分析。比值计算基于原始数据的测量值，图像质量由两名有经验的放射科医生进行盲法和独立评估，使用五分制评分。

结果

1.5 T 组的平均采集时间为 14.58 +/- 0.1 分钟，3.0 T 组为 16.40 +/- 0.2 分钟。与 1.5 T 相比，所有评估的冠状动脉节段的总体 SNR 在 3.0 T 时更高（3.0 T 时为 74.0 +/- 42.1，1.5 T 时为 50.2 +/- 20.2，P =.04）。与 1.5 T 相比，3.0 T 时冠状动脉与心肌之间的总体 CNR 显著增加（3.0 T 时为 40.1 +/- 21.9，1.5 T 时为 24.4 +/- 17.2，P =.01）。两种方法之间，冠状动脉与心外膜脂肪之间的总体 CNR 无显著差异（P =.08，NS）。与 1.5 T 相比，3.0 T 的整体图像质量更好（3.0 T 时为 2.28 +/- 0.71，1.5 T 时为 1.92 +/- 0.38，P =.004）。