Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, CSC E1/322, Madison, WI 53729, USA.
Acad Radiol. 2010 Nov;17(11):1394-400. doi: 10.1016/j.acra.2010.05.022. Epub 2010 Jul 22.
Gadofosveset trisodium is a blood-pool contrast agent (BPA) that shows a less pronounced r1 relaxivity advantage over gadobenate dimeglumine at 3T than at 1.5T. However, there are few data on image quality during first-pass imaging of the thoracic vasculature with gadofosveset trisodium at 3 T. Therefore, it was the aim of this study to compare first-pass imaging characteristics of gadofosveset trisodium to gadobenate dimeglumine during time-resolved contrast-enhanced three-dimensional magnetic resonance angiography (CE MRA) at 3 T.
Twenty volunteers underwent time-resolved CE MRA on a 3 T magnetic resonance (MR) system with a standard eight-channel phased-array surface coil, receiving either gadofosveset trisodium (blood pool agent [BPA], n = 10) or gadobenate dimeglumine (standard contrast agent, [SCA], n = 10). Image quality was assessed by two independent readers using a Likert scale ranging from 0 = poor quality to 3 = excellent quality, and relative signal-to-noise and contrast-to-noise ratios were calculated.
Equally good to excellent first-pass image quality was confirmed for time-resolved CE MRA using BPA and SCA (arteries, 2.8 ± 0.2 and 2.6 ± 0.4; veins, 2.5 ± 0.3 and 2.2 ± 0.4; artifacts, 2.4 ± 0.2 and 2.3 ± 0.1). Signal-to-noise and contrast-to-noise ratios showed nonsignificant differences, except for left subclavian artery values. There was an overall nonsignificant superiority in signal-to-noise and contrast-to-noise ratios for standard contrast agent in arterial values and BPA regarding venous values.
Despite a markedly decreased r1/r2 relaxivity ratio, first-pass imaging characteristics of gadofosveset trisodium and gadobenate dimeglumine are equally well suited for first pass time-resolved CE MRA at 3 T.
钆佛醇三钠是一种血池对比剂（BPA），与 1.5T 相比，在 3T 时其 r1 弛豫率优势较钆贝葡胺稍低。然而，在 3T 时使用钆佛醇三钠进行胸部血管初次通过成像的图像质量数据较少。因此，本研究旨在比较 3T 时间分辨对比增强三维磁共振血管造影（CE MRA）中钆佛醇三钠与钆贝葡胺的初次通过成像特征。
20 名志愿者在 3T 磁共振（MR）系统上进行时间分辨 CE MRA 检查，使用标准的 8 通道相控阵表面线圈，分别接受钆佛醇三钠（血池造影剂 [BPA]，n=10）或钆贝葡胺（标准造影剂，[SCA]，n=10）。由两位独立的读者使用 0 到 3 的 Likert 量表对图像质量进行评估，范围为 0=质量差到 3=质量好，并计算相对信噪比和对比噪声比。
使用 BPA 和 SCA 进行时间分辨 CE MRA 时，初次通过图像质量被证实为良好到优秀（动脉：2.8±0.2 和 2.6±0.4；静脉：2.5±0.3 和 2.2±0.4；伪影：2.4±0.2 和 2.3±0.1）。信号与噪声比和对比噪声比无显著差异，左锁骨下动脉除外。在动脉值中，标准造影剂的信号与噪声比和对比噪声比具有整体优势，而在静脉值中 BPA 具有优势。
尽管 r1/r2 弛豫率明显降低，但在 3T 时，钆佛醇三钠和钆贝葡胺的初次通过成像特征同样适用于初次通过时间分辨 CE MRA。
