血清中双峰驼成骨生物标志物的昼夜节律。

Circadian rhythm of bone formation biomarkers in serum of dromedary camels.

机构信息

College of Agriculture and Veterinary Medicine, Al-Qassim University, Buraydah, P.O. Box 1482, Al-Qassim, Saudi Arabia.

出版信息

Res Vet Sci. 2010 Dec;89(3):455-9. doi: 10.1016/j.rvsc.2010.03.024. Epub 2010 Apr 18.

DOI:10.1016/j.rvsc.2010.03.024

PMID:20400166

Abstract

The circadian rhythm of biomarkers of bone formation including osteocalcin and bone alkaline phosphatase (BAP) was studied in the serum of dromedary camels. Blood samples were collected every 60 min for 24h from 10 healthy adult female camels. ELISA was used to determine the concentrations of serum osteocalcin and BAP. The results showed a marked fluctuation in the concentration of osteocalcin during the 24h period with minimum and maximum levels at 13:00 (01:00 pm) and 18:00 (06:00 pm), respectively. Slight fluctuation was observed in the concentration of BAP with minimum and maximum levels at 01:00 am and 12:00 pm, respectively. The correlation between the two biomarkers was weak. It was concluded that it is important to fix the time of blood sampling for analysis of osteocalcin concentrations, but not for BAP.

摘要

研究了 10 只健康成年雌性单峰驼血清中成骨生物标志物骨钙素和骨碱性磷酸酶（BAP）的昼夜节律。每 60 分钟采集一次血样，持续 24 小时。采用 ELISA 法测定血清骨钙素和 BAP 的浓度。结果表明，骨钙素浓度在 24 小时内呈明显波动，最低值和最高值分别在 13:00（下午 1 点）和 18:00（下午 6 点）。BAP 浓度略有波动，最低值和最高值分别在凌晨 1 点和中午 12 点。这两个生物标志物之间的相关性较弱。结论是，分析骨钙素浓度时，采血时间很重要，但分析 BAP 时则不重要。