Pestronk A, Drachman D B
Science. 1978 Mar 17;199(4334):1223-5. doi: 10.1126/science.204007.
Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with alpha-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.
运动神经末梢的发芽是由突触前阻断或废用引起的骨骼肌功能性去神经支配所诱发的。通过形态测量确定的发芽量与接头外乙酰胆碱受体水平相关。用α-银环蛇毒素阻断乙酰胆碱受体会抑制发芽。接头外乙酰胆碱受体可能在引发运动神经末梢发芽中起重要作用。
