Hart D A, Krause G, Martin L, Garlepp M, Fritzler M J
Joint Injury and Diseases Research Group, University of Calgary, Health Science Centre, Alberta.
Clin Invest Med. 1991 Feb;14(1):55-62.
Murine models of systemic lupus erythematosus exhibit some, but not all of the characteristics of human disease. Disease progression in the animal models is related to autoantibodies, genetics, and inflammatory processes. In this report the effects of two bacterial biological response modifiers (BRM) on disease progression in the MRL-lpr model were investigated. The two BRM tested were C. parvum and Bacillus-Calmette-Guerin (BCG), both of which are stimulators of the reticuloendothelial system and both of which have been shown by others to influence disease progression in NZB/W mice. Treatment of 10-week-old mice with C. parvum led to transient alterations in hepatosplenomegaly and plasma proteinase regulation, which then returned to control values. Treatment with BCG led to even more transient effects on the mice. Neither BRM appeared to impact on disease-associated alterations in autoantibody titres, hepatosplenomegaly, or elevations in plasma proteinase activity. Likewise, treatment of 17-week-old MRL-lpr mice with C. parvum did not influence disease progression as evidenced by survival, autoantibody production, or hepatosplenomegaly. Therefore, in contrast to the NZB/W strain, treatment of the MRL-lpr strain with these BRM does not appear to impact on disease progression. This difference may be due to the influence of the lpr accelerator gene in this model.
系统性红斑狼疮的小鼠模型展现出了人类疾病的一些而非全部特征。动物模型中的疾病进展与自身抗体、遗传学及炎症过程有关。在本报告中，研究了两种细菌生物反应调节剂（BRM）对MRL-lpr模型中疾病进展的影响。所测试的两种BRM为微小隐孢子虫和卡介苗（BCG），二者均为网状内皮系统的刺激剂，且其他研究已表明它们会影响NZB/W小鼠的疾病进展。用微小隐孢子虫治疗10周龄小鼠会导致肝脾肿大和血浆蛋白酶调节出现短暂改变，之后又恢复至对照值。用卡介苗治疗对小鼠产生的影响更为短暂。两种BRM似乎均未对自身抗体滴度、肝脾肿大或血浆蛋白酶活性升高这些与疾病相关的改变产生影响。同样，用微小隐孢子虫治疗17周龄的MRL-lpr小鼠，并未影响疾病进展，这一点从生存率、自身抗体产生或肝脾肿大方面均可得到证明。因此，与NZB/W品系不同，用这些BRM治疗MRL-lpr品系似乎不会影响疾病进展。这种差异可能归因于该模型中lpr加速基因的影响。
