Koch Felix P, Walter Christian, Hansen Torsten, Jäger Elke, Wagner Wilfried
Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Mainz, Germany.
Oral Maxillofac Surg. 2011 Mar;15(1):63-6. doi: 10.1007/s10006-010-0224-y.
A 59-year-old male patient was referred to the hospital with exposed bone measuring 10 mm in diameter in the posterior, left-side region of the lower jaw. Two months previous, the first molar had been extracted. The patient had contracted renal cell carcinoma and had been treated by nephrectomy in 2003. Soft tissue metastases occurred. After initial therapy with interferon and vinblastine, a relapse occurred and the therapy was changed to sorafenib, followed by sunitinib. Osteonecrosis of the lower jaw appeared 1 year after initial and exclusive therapy with sunitinib.
Bisphosphonates had never been applied. With increasing application of multi-kinase inhibitors, complications due to osteonecrosis could occur more frequently.
一名59岁男性患者因下颌骨左侧后部出现直径10毫米的暴露骨而被转诊至医院。两个月前拔除了第一磨牙。该患者曾患肾细胞癌，并于2003年接受了肾切除术。出现了软组织转移。在使用干扰素和长春碱进行初始治疗后复发，治疗改为索拉非尼，随后使用舒尼替尼。在仅使用舒尼替尼进行初始治疗1年后出现了下颌骨坏死。
从未应用过双膦酸盐。随着多激酶抑制剂应用的增加，骨坏死引起的并发症可能会更频繁地发生。
