Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Addiction. 2010 Apr;105(4):686-98. doi: 10.1111/j.1360-0443.2009.02829.x.
To determine the added risk of opioid problem use (OPU) in youth with marijuana/alcohol problem use (MAPU).
A total of 475 youth (ages 14-21 years) with OPU + MAPU were compared to a weighted sample of 475 youth with MAPU only (i.e. no OPU) before and after propensity score matching on gender, age, race, level of care and weekly use of marijuana/alcohol. Youth were recruited from 88 drug treatment sites participating in eight Center for Substance Abuse Treatment-funded grants. At treatment intake, participants were administered the Global Appraisal of Individual Need to elicit information on demographic, social, substance, mental health, human immunodeficiency virus (HIV), physical and legal characteristics. Odds ratios with confidence intervals were calculated.
The added risk of OPU among MAPU youth was associated with greater comorbidity; higher rates of psychiatric symptoms and trauma/victimization; greater needle use and sex-related HIV risk behaviours; and greater physical distress. The OPU + MAPU group was less likely to be African American or other race and more likely to be aged 15-17 years, Caucasian; report weekly drug use at home and among peers; engage in illegal behaviors and be confined longer; have greater substance abuse severity and polydrug use; and use mental health and substance abuse treatment services.
These findings expand upon the existing literature and highlight the substantial incremental risk of OPU on multiple comorbid areas among treatment-seeking youth. Further evaluation is needed to assess their outcomes following standard drug treatment and to evaluate specialized interventions for this subgroup of severely impaired youth.
确定在同时存在阿片类药物问题使用(OPU)和大麻/酒精问题使用(MAPU)的年轻人中,OPU 增加的风险。
共有 475 名 OPU+MAPU 青少年与经过性别、年龄、种族、治疗级别和大麻/酒精每周使用量的倾向评分匹配后的 475 名仅 MAPU(即无 OPU)青少年进行了比较。这些青少年来自参与八项中心药物滥用治疗资助项目的 88 个药物治疗场所。在治疗开始时,参与者接受了全球个体需求评估,以获取人口统计学、社会、物质、心理健康、人类免疫缺陷病毒(HIV)、身体和法律特征方面的信息。计算了比值比及其置信区间。
MAPU 青少年中 OPU 的附加风险与更高的共病率;更高的精神症状和创伤/受害率;更多的针具使用和与性相关的 HIV 风险行为;以及更大的身体不适有关。OPU+MAPU 组中,非裔美国人或其他种族的比例较低,15-17 岁的青少年比例较高,白种人;报告在家中和同龄人中每周使用药物;从事非法行为并被监禁更长时间;物质滥用严重程度和多药使用程度更高;以及更多地使用心理健康和物质滥用治疗服务。
这些发现扩展了现有文献,并强调了在寻求治疗的年轻人中,OPU 在多个共病领域的风险显著增加。需要进一步评估他们在标准药物治疗后的结果,并评估针对这一严重受损青少年亚组的专门干预措施。