[在肺腺癌小鼠模型中(11)C-PDT与(18)F-FDG的生物分布及PET成像比较]

[Comparison of the biodistribution and PET imaging with (11)C-PDT and (18)F-FDG in the mouse model of lung adenocarcinoma].

作者信息

Zhang Tao, Zhou Nai-kang, Zhang Jin-ming, Liang Chao-yang, Liu Xi, Tian Xiao-dong

机构信息

Department of Thoracic Surgery, General Hospital of PLA, Beijing, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2010 Feb;32(2):103-6.

PMID:20403239

Abstract

OBJECTIVE

The objective of this study was to compare the biodistribution and PET imaging of (11)C-PDT and (18)F-FDG in a mouse model of lung adenocarcinoma, and to evaluate the value of (11)C-PDT as a new tracer for PET imaging of lung cancer.

METHODS

Twenty four lung adenocarcinoma-bearing mice were randomly divided into two groups, 12 each. The mice received (11)C-PDT or (18)F-FDG injection i.v. respectively. The biodistribution of (11)C-PDT or (18)F-FDG in the mice was measured with a well-gamma detector at 60 min after injection. The PET imagings of mice were performed using either of the two tracers.

RESULTS

Considerable uptake of the both radioactive tracers in the tumors was observed. The tumor uptake of (11)C-PDT [(0.65 +/- 0.20)%ID/g] was significantly lower than that of (18)F-FDG [(7.44 +/- 1.56)%ID/g, P < 0.01]. In the (11)C-PDT group, the highest uptake was observed in the liver, kidney and blood in a successively declining order, while the highest uptake of (18)F-FDG was seen in a order of heart, tumor and kidneys. The tumor/muscle ratio of (11)C-PDT uptake was relatively high (2.02 +/- 0.56), but still lower than that of (18)F-FDG (2.95 +/- 0.49, P < 0.01). All values of other tumor/organ ratios (T/NT) of (11)C-PDT uptake were < 2. High radioactive uptake was showed in the tumor and abdominal organs on PET images in the tumor-bearing mice injected with (11)C-PDT, and (18)F-FDG uptake was showed in the heart, tumor and abdominal organs. The tumor PET images with (11)C-PDT and (18)F-FDG were all clear.

CONCLUSION

The uptake of (11)C-PDT in lung cancer is higher than that in muscle tissues, and pulmonary cancers can be detected by PET imaging. (11)C-PDT may be a promising PET tracer for lung cancers.

摘要

目的

本研究旨在比较（11）C - PDT和（18）F - FDG在肺腺癌小鼠模型中的生物分布及PET成像情况，并评估（11）C - PDT作为肺癌PET成像新型示踪剂的价值。

方法

将24只荷肺腺癌小鼠随机分为两组，每组12只。小鼠分别经静脉注射（11）C - PDT或（18）F - FDG。注射后60分钟，用井型γ探测器测量（11）C - PDT或（18）F - FDG在小鼠体内的生物分布。使用这两种示踪剂之一对小鼠进行PET成像。

结果

观察到两种放射性示踪剂在肿瘤中均有明显摄取。（11）C - PDT的肿瘤摄取量[（0.65±0.20）%ID/g]显著低于（18）F - FDG[（7.44±1.56）%ID/g，P<0.01]。在（11）C - PDT组中，肝脏、肾脏和血液中的摄取量依次最高且呈下降趋势，而（18）F - FDG摄取量最高的顺序为心脏、肿瘤和肾脏。（11）C - PDT摄取的肿瘤/肌肉比值相对较高（2.02±0.56），但仍低于（18）F - FDG（2.95±0.49，P<0.01）。（11）C - PDT摄取的所有其他肿瘤/器官比值（T/NT）均<2。在注射（11）C - PDT的荷瘤小鼠的PET图像上，肿瘤和腹部器官显示出高放射性摄取，而（18）F - FDG摄取显示在心脏、肿瘤和腹部器官。（11）C - PDT和（18）F - FDG的肿瘤PET图像均清晰。