Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan.
Semin Cell Dev Biol. 2010 Sep;21(7):671-6. doi: 10.1016/j.semcdb.2010.04.002. Epub 2010 Apr 18.
In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss the role of PI3P in autophagosome formation from three different perspectives: PI3-kinase, PI3-binding proteins, and PI3-phosphatase. Recent developments in this field suggest that the local PI3P concentration is dynamically regulated during autophagy, and that this molecule is critical to the proper control of autophagy.
在自噬中，细胞质底物通过称为自噬体的膜结构靶向溶酶体进行降解。自噬体的形成是自噬活性的主要调节点，PI3P 在这个过程中起着核心作用。在这篇综述中，我们将从三个不同的角度讨论 PI3P 在自噬体形成中的作用：PI3-激酶、PI3 结合蛋白和 PI3-磷酸酶。该领域的最新进展表明，自噬过程中局部 PI3P 浓度是动态调节的，并且该分子对自噬的正确控制至关重要。
