Université de Toulouse, UPS, LSPCMIB (Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique), 118 Route de Narbonne, F-31062 Toulouse Cedex 9, France.
Eur J Med Chem. 2010 Jul;45(7):3019-26. doi: 10.1016/j.ejmech.2010.03.031. Epub 2010 Mar 25.
A novel series of hydrazones derived from syringaldehyde and their antioxidant properties have been explored. Several employed methods such as scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(+)) radical cation expressed as Trolox equivalent antioxidant capacity (TEAC), inhibition of superoxide anion (O(2)(-)) generation and of human cell-mediated low-density lipoprotein oxidation (monitored by the formation of TBARS) exhibited their potent antioxidant properties. The carbonyl scavenger efficacy was also evaluated by measuring the ability to decrease the protein carbonyl content in cells challenged with oxidized LDL. In this report, we discuss about the synthesis of hydrazones and their dual biological role, antioxidant and carbonyl scavenger for further application in atherosclerosis.
我们探索了一系列新型的来源于丁香醛的腙类化合物及其抗氧化性能。采用了几种方法，如对 2,2-二苯基-1-苦肼基（DPPH）自由基和 2,2'-联氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS(+)）自由基阳离子的清除作用，用 Trolox 当量抗氧化能力（TEAC）表示，抑制超氧阴离子（O(2)(-))生成和人细胞介导的低密度脂蛋白氧化（通过 TBARS 的形成来监测），表现出它们强大的抗氧化性能。还通过测量氧化型 LDL 攻击细胞时降低细胞内蛋白羰基含量的能力来评估羰基清除剂的功效。在本报告中，我们讨论了腙类化合物的合成及其双重生物学作用，即抗氧化剂和羰基清除剂，以进一步应用于动脉粥样硬化。
