Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1679-96. doi: 10.1098/rstb.2010.0025.
Integral membrane proteins that contribute to function of the blood-testes barrier (BTB) in mice include claudins 3, 5 and 11 and occludin. Although claudin 11 is expressed throughout all stages of the seminiferous epithelial cycle, claudins 3 and 5 have specific expression at stage VIII. These differences in protein expression suggest that the interactions among, and functions of, these integral membrane proteins may shift over the course of the seminiferous epithelial cycle. Also, differences in expression among rodent species and men may make interpretation of studies across species challenging. This review will discuss the characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB.
参与小鼠血睾屏障 (BTB) 功能的完整膜蛋白包括 Claudin 3、5 和 11 以及 Occludin。虽然 Claudin 11 在精母细胞上皮周期的所有阶段都有表达,但 Claudin 3 和 5 仅在第 VIII 阶段特异性表达。这些蛋白表达的差异表明,这些完整膜蛋白之间的相互作用和功能可能会在精母细胞上皮周期中发生变化。此外,不同啮齿动物物种和人类之间的表达差异可能使得跨物种研究的解释具有挑战性。本综述将讨论 Claudin 和 Occludin 的特性;这些完整膜蛋白在精母细胞上皮中的表达、调节和功能;以及这些特性如何与 BTB 的独特特征相关。