Knapstein P G, Kreienberg R, Beck T, Mahlke M, Mitze M, Düber C
Frauenklinik, Johannes-Gutenberg-Universität Mainz.
Geburtshilfe Frauenheilkd. 1991 Feb;51(2):156-60. doi: 10.1055/s-2007-1023696.
Three patients suffering from very advanced primary cancers of the cervix uteri (FIGO II B or III B) were treated. By preoperative selective perfusion of both uterine arteries, using cis-platinum alone, a distinct reduction of the tumour volume was achieved. This was demonstrated clinically and also by CAT scan and NMR technique. The elevated serum CEA and SCC levels decreased to normal values. The histomorphology of the Wertheim-Meigs specimens revealed no tumour invasion of the initially infiltrated parametria. This treatment modality has been developed to minimise the toxic side effects of the inductive (neo-adjuvant) chemotherapy for cervical cancers.
对三名患有非常晚期子宫颈原发性癌（国际妇产科联盟（FIGO）II B期或III B期）的患者进行了治疗。通过术前仅使用顺铂对双侧子宫动脉进行选择性灌注，肿瘤体积明显缩小。这在临床上以及通过计算机断层扫描（CAT）和核磁共振（NMR）技术都得到了证实。血清癌胚抗原（CEA）和鳞状细胞癌抗原（SCC）水平升高降至正常范围。韦特海姆-梅格斯手术标本的组织形态学显示，最初浸润的宫旁组织未出现肿瘤侵犯。开发这种治疗方式是为了将宫颈癌诱导（新辅助）化疗的毒副作用降至最低。
