小细胞胆囊癌合并副肿瘤性低钠血症：一例报告及文献复习
Small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia: a case report and literature review.
作者信息
Ng Esther S, Venkateswaran Kotamma, Ganpathi Shridhar I, Chuah Benjamin Y
机构信息
Department of Medicine, National University Health System, Singapore, Singapore.
出版信息
J Gastrointest Cancer. 2010 Dec;41(4):264-8. doi: 10.1007/s12029-010-9151-2.
INTRODUCTION
Gallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis.
CASE REPORT
We report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy.
DISCUSSION
There have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma.
CONCLUSION
Symptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome.
引言
胆囊癌与多种副肿瘤综合征相关。这些可能是促使临床医生做出诊断的首发表现。
病例报告
我们报告一例小细胞胆囊癌并发副肿瘤性低钠血症的病例。铂类化疗进一步加重了低钠血症。
讨论
此前尚无胆囊癌并发副肿瘤性低钠血症的报道。我们讨论了该问题的处理方法，并对与胆囊癌相关的其他副肿瘤综合征进行了简短的文献综述。
结论
胆囊癌的症状和体征可能隐匿。如果患者出现副肿瘤综合征的症状和体征，需要进行全面检查。
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