Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA.
Allergy Asthma Proc. 2010 Mar-Apr;31(2):89-95. doi: 10.2500/aap.2010.31.3328.
A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the innate immune system, including inherent properties of allergens, the active role of airway epithelium, and the central importance of dendritic cells together with the pathophysiological processes in which these factors interact. Implications of these processes for asthma therapy, with a focus on anti-IgE treatment are also discussed.
遗传易感性和环境影响的复杂相互作用导致了过敏性哮喘的临床表现。本文探讨了最近确定的遗传标记物和环境因素，这些因素有助于哮喘的发病。重点是先天免疫系统的各个方面，包括过敏原的固有特性、气道上皮的积极作用以及树突状细胞的核心重要性，以及这些因素相互作用的病理生理过程。还讨论了这些过程对哮喘治疗的影响，重点是抗 IgE 治疗。
