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本文引用的文献

1
Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men.血浆有机氯水平与男性非霍奇金淋巴瘤风险的队列研究。
Epidemiology. 2010 Mar;21(2):172-80. doi: 10.1097/EDE.0b013e3181cb610b.
2
Organochlorines and risk of non-Hodgkin lymphoma.有机氯与非霍奇金淋巴瘤风险
Int J Cancer. 2007 Dec 15;121(12):2767-75. doi: 10.1002/ijc.23005.
3
Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes.血浆多氯联苯和有机氯农药水平与主要淋巴瘤亚型的风险
Occup Environ Med. 2008 Feb;65(2):132-40. doi: 10.1136/oem.2007.033548. Epub 2007 Aug 15.
4
Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts.外周血中的多氯联苯水平与非霍奇金淋巴瘤:来自三个队列的报告。
Cancer Res. 2007 Jun 1;67(11):5545-52. doi: 10.1158/0008-5472.CAN-06-3906.
5
Polychlorinated biphenyls and non-Hodgkin lymphoma.多氯联苯与非霍奇金淋巴瘤
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):373-6. doi: 10.1158/1055-9965.EPI-07-0055. Epub 2007 Mar 2.
6
Persistent organochlorine chemicals in plasma and risk of non-Hodgkin's lymphoma.血浆中持久性有机氯化学物质与非霍奇金淋巴瘤风险
Cancer Res. 2005 Dec 1;65(23):11214-26. doi: 10.1158/0008-5472.CAN-05-1755.
7
Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.有机氯农药和多氯联苯的脂肪组织水平与非霍奇金淋巴瘤风险
Environ Health Perspect. 2004 Jun;112(8):854-61. doi: 10.1289/ehp.6726.
8
Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma.非霍奇金淋巴瘤病因中有机卤素化合物浓度与爱泼斯坦-巴尔病毒抗原抗体滴度的病例对照研究。
Leuk Lymphoma. 2001 Aug;42(4):619-29. doi: 10.3109/10428190109099322.
9
Adipose tissue concentrations of dioxins and dibenzofurans, titers of antibodies to Epstein-Barr virus early antigen and the risk for non-Hodgkin lymphoma.脂肪组织中二噁英和二苯并呋喃的浓度、抗爱泼斯坦-巴尔病毒早期抗原抗体滴度与非霍奇金淋巴瘤风险
Environ Res. 2001 Oct;87(2):99-107. doi: 10.1006/enrs.2001.4295.
10
Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women.绝经后女性血浆性甾体激素水平与乳腺癌风险
J Natl Cancer Inst. 1998 Sep 2;90(17):1292-9. doi: 10.1093/jnci/90.17.1292.

血浆有机氯水平与护士健康研究中非霍奇金淋巴瘤的风险。

Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.

机构信息

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1381-4. doi: 10.1158/1055-9965.EPI-10-0125. Epub 2010 Apr 20.

DOI:10.1158/1055-9965.EPI-10-0125
PMID:20406963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2866053/
Abstract

Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with the risk of non-Hodgkin lymphoma (NHL). In a case-control study nested within the Nurses' Health Study, a prospective cohort of U.S. women, we measured concentrations of PCBs and p,p'-DDE in blood samples from 145 women diagnosed with NHL at least 6 months after blood draw and 290 age- and race-matched controls. We used conditional logistic regression to estimate the odds ratios and 95% confidence intervals for each quartile of exposure relative to the lowest quartile. We also evaluated these associations for major histologic subtypes of NHL. There was no consistent evidence of an association of p,p'-DDE, total PCBs, immunotoxic, or individual PCB congeners with risk of NHL. These results do not support the hypothesis of a positive association between PCB exposure and development of NHL.

摘要

许多研究报告指出,环境中多氯联苯(PCBs)和 p,p'-二氯二苯二氯乙烯(p,p'-DDE)的暴露与非霍奇金淋巴瘤(NHL)的风险呈正相关。在一项巢式病例对照研究中,我们在美国女性护士健康研究这一前瞻性队列中,测量了 145 名 NHL 确诊至少 6 个月后采血的女性和 290 名年龄和种族匹配的对照者的血液样本中 PCBs 和 p,p'-DDE 的浓度。我们使用条件逻辑回归估计每个四分位暴露相对于最低四分位的比值比和 95%置信区间。我们还评估了这些关联与 NHL 的主要组织学亚型。p,p'-DDE、总 PCBs、免疫毒性或个别 PCB 同系物与 NHL 风险之间没有一致的关联证据。这些结果不支持 PCB 暴露与 NHL 发展之间存在正相关的假设。