Engel Lawrence S, Lan Qing, Rothman Nathaniel
Department of Epidemiology, Memorial Sloan-Kettering Cancer Center, Epidemiology Service, 307 E. 63rd St., 3rd Floor, New York, NY 10021, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):373-6. doi: 10.1158/1055-9965.EPI-07-0055. Epub 2007 Mar 2.
Several epidemiologic studies suggest that polychlorinated biphenyl (PCB) levels measured in peripheral blood or adipose tissue are related to increased risk of non-Hodgkin lymphoma (NHL) and, therefore, may be at least partially responsible for the rising incidence of NHL unrelated to HIV infection in recent decades. Case-control studies that measured PCBs in blood, adipose tissue, or household carpet dust, at the time of diagnosis, have observed elevated NHL risk associated with concentrations of either total PCBs or of specific congeners. Similar associations have been found in a number of prospective cohorts. These associations do not seem to be due to confounding by other organochlorines or by other known NHL risk factors. These results support evidence of PCB carcinogenicity from animal studies. However, interpretation of the epidemiologic evidence is limited by the wide range in measurement precision across congeners and by the moderate to high correlation among many congeners. Occupational cohort studies provide very limited support for a relationship between PCBs and NHL. In conclusion, there is mounting evidence of a relationship between certain PCBs and risk of NHL, but important questions remain, especially regarding the magnitude, timing, and causality of that relationship.
多项流行病学研究表明，在外周血或脂肪组织中测得的多氯联苯（PCB）水平与非霍奇金淋巴瘤（NHL）风险增加有关，因此，可能至少部分导致了近几十年来与HIV感染无关的NHL发病率上升。在诊断时对血液、脂肪组织或家用地毯灰尘中的多氯联苯进行测量的病例对照研究发现，总多氯联苯或特定同系物的浓度与NHL风险升高有关。在一些前瞻性队列研究中也发现了类似的关联。这些关联似乎并非由其他有机氯或其他已知的NHL风险因素造成的混杂所致。这些结果支持了动物研究中多氯联苯致癌性的证据。然而，流行病学证据的解释受到各同系物测量精度差异较大以及许多同系物之间存在中度至高相关性的限制。职业队列研究对多氯联苯与NHL之间的关系提供的支持非常有限。总之，越来越多的证据表明某些多氯联苯与NHL风险之间存在关联，但重要问题仍然存在，尤其是关于这种关联的程度、时间和因果关系。
