Rusina Robert, Barek Stephane, Vaculin Simon, Azérad Jean, Rokyta Richard
Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
Acta Neurobiol Exp (Wars). 2010;70(1):47-55. doi: 10.55782/ane-2010-1773.
While the effect of cortex stimulation on pain control is widely accepted, its physiological basis remains poorly understood. We chose an animal model of pain to study the influence of sensorimotor cortex stimulation on tooth pulp stimulation evoked potentials (TPEPs). Fifteen awake rats implanted with tooth pulp, cerebral cortex, and digastric muscle electrodes were divided into three groups, receiving 60 Hz, 40 Hz and no cortical stimulation, respectively. TPEPs were recorded before, one, three and five hours after continuous stimulation. We observed an inverse relationship between TPEP amplitude and latency with increasing tooth pulp stimulation. The amplitudes of the early components of TPEPs increased and their latency decreased with increasing tooth pulp stimulation intensity. Cortical stimulation decreased the amplitude of TPEPs; however, neither the latencies of TPEPs nor the jaw-opening reflex were changed after cortical stimulation. The decrease in amplitude of TPEPs after cortical stimulation may reflect its anti-nociceptive effect.
虽然皮质刺激对疼痛控制的作用已被广泛接受，但其生理基础仍知之甚少。我们选择了一种疼痛动物模型来研究感觉运动皮质刺激对牙髓刺激诱发电位（TPEPs）的影响。将15只植入了牙髓、大脑皮质和二腹肌电极的清醒大鼠分为三组，分别接受60Hz、40Hz的皮质刺激以及不进行皮质刺激。在连续刺激前、刺激后1小时、3小时和5小时记录TPEPs。我们观察到随着牙髓刺激增加，TPEP波幅与潜伏期呈反比关系。随着牙髓刺激强度增加，TPEPs早期成分的波幅增加，潜伏期缩短。皮质刺激降低了TPEPs的波幅；然而，皮质刺激后TPEPs的潜伏期和张口反射均未改变。皮质刺激后TPEPs波幅的降低可能反映了其抗伤害感受作用。
