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攻击与焦虑:社会环境与神经生物学联系

Aggression and anxiety: social context and neurobiological links.

作者信息

Neumann Inga D, Veenema Alexa H, Beiderbeck Daniela I

机构信息

Department of Behavioural and Molecular Neuroendocrinology, University of Regensburg Regensburg, Germany.

出版信息

Front Behav Neurosci. 2010 Mar 30;4:12. doi: 10.3389/fnbeh.2010.00012. eCollection 2010.

Abstract

Psychopathologies such as anxiety- and depression-related disorders are often characterized by impaired social behaviours including excessive aggression and violence. Excessive aggression and violence likely develop as a consequence of generally disturbed emotional regulation, such as abnormally high or low levels of anxiety. This suggests an overlap between brain circuitries and neurochemical systems regulating aggression and anxiety. In this review, we will discuss different forms of male aggression, rodent models of excessive aggression, and neurobiological mechanisms underlying male aggression in the context of anxiety. We will summarize our attempts to establish an animal model of high and abnormal aggression using rats selected for high (HAB) vs. low (LAB) anxiety-related behaviour. Briefly, male LAB rats and, to a lesser extent, male HAB rats show high and abnormal forms of aggression compared with non-selected (NAB) rats, making them a suitable animal model for studying excessive aggression in the context of extremes in innate anxiety. In addition, we will discuss differences in the activity of the hypothalamic-pituitary-adrenal axis, brain arginine vasopressin, and the serotonin systems, among others, which contribute to the distinct behavioural phenotypes related to aggression and anxiety. Further investigation of the neurobiological systems in animals with distinct anxiety phenotypes might provide valuable information about the link between excessive aggression and disturbed emotional regulation, which is essential for understanding the social and emotional deficits that are characteristic of many human psychiatric disorders.

摘要

诸如焦虑和抑郁相关障碍等精神病理学通常以包括过度攻击和暴力在内的社会行为受损为特征。过度攻击和暴力很可能是由于普遍紊乱的情绪调节所致,比如焦虑水平异常高或低。这表明调节攻击和焦虑的脑回路与神经化学系统之间存在重叠。在本综述中,我们将讨论男性攻击的不同形式、过度攻击的啮齿动物模型以及在焦虑背景下男性攻击背后的神经生物学机制。我们将总结我们尝试使用根据高(HAB)与低(LAB)焦虑相关行为选择的大鼠建立高攻击性和异常攻击性动物模型的情况。简而言之,与未选择的(NAB)大鼠相比,雄性LAB大鼠以及在较小程度上雄性HAB大鼠表现出高度和异常形式的攻击行为,这使它们成为研究先天焦虑极端情况下过度攻击行为的合适动物模型。此外,我们将讨论下丘脑 - 垂体 - 肾上腺轴、脑精氨酸加压素和血清素系统等的活性差异,这些差异导致了与攻击和焦虑相关的不同行为表型。对具有不同焦虑表型的动物的神经生物学系统进行进一步研究,可能会提供有关过度攻击与紊乱情绪调节之间联系的有价值信息,这对于理解许多人类精神疾病所特有的社会和情感缺陷至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0d/2854527/804d5541c851/fnbeh-04-00012-g001.jpg

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