Rarinca Viorica, Hritcu Luminita Diana, Burducea Marian, Plavan Gabriel, Lefter Radu, Burlui Vasile, Romila Laura, Ciobică Alin, Todirascu-Ciornea Elena, Barbacariu Cristian-Alin
Doctoral School of Geosciences, Faculty of Geography and Geology, "Alexandru Ioan Cuza" University of Iasi, No 20A, Carol I Avenue, 700505 Iasi, Romania.
Doctoral School of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iași, Carol I Avenue, 20A, 700505 Iasi, Romania.
Curr Issues Mol Biol. 2024 Dec 15;46(12):14168-14189. doi: 10.3390/cimb46120848.
Although pesticides have been a constant concern for decades, in the last ten years, public discussions and scientific research have emphasized their impact on human health and the environment, drawing increased attention to the problems associated with their use. The association of environmental stressors such as pesticides with a sugar-rich diet can contribute to the growing global metabolic disease epidemic through overlapping mechanisms of insulin resistance, inflammation, and metabolic dysregulation. The main aim of this study was to evaluate the behavioral effects of the exposure of Silver crucian carp () to a commercial insecticide formulation containing fipronil, pyriproxyfen, and other additives, as well as sucrose and their mixtures. The behavioral responses in the T-test showed significant abnormalities in the exploratory activity evocative of memory deficits and an increased degree of anxiety in the groups of fish treated with the insecticide formulation and the mixture of the insecticide with sucrose. Aggression, quantified in the mirror-biting test, as biting and the frequency of approaches to the mirror contact zone, was significantly decreased only in the insecticide and sucrose group. All three groups showed behavioral changes reflective of toxicity, but only the combination of the two stress factors, environmental (insecticide) and metabolic (sucrose intake), resulted in pronounced memory alterations.
尽管几十年来农药一直备受关注，但在过去十年中，公众讨论和科学研究都强调了它们对人类健康和环境的影响，这使得人们对与农药使用相关的问题给予了更多关注。诸如农药之类的环境应激源与高糖饮食的关联，可通过胰岛素抵抗、炎症和代谢失调等重叠机制，促使全球代谢性疾病流行趋势加剧。本研究的主要目的是评估银鲫暴露于含有氟虫腈、吡丙醚及其他添加剂的商业杀虫剂配方、蔗糖及其混合物中的行为效应。T 检验中的行为反应显示，在用杀虫剂配方以及杀虫剂与蔗糖混合物处理的鱼群中，探索活动出现显著异常，这表明存在记忆缺陷，且焦虑程度增加。在咬镜试验中量化的攻击性，如咬镜行为以及接近镜子接触区的频率，仅在杀虫剂和蔗糖组显著降低。所有三组都表现出反映毒性的行为变化，但只有环境（杀虫剂）和代谢（蔗糖摄入）这两种应激因素的组合导致了明显的记忆改变。
