1型糖尿病的小鼠模型
Mouse Models for Type 1 Diabetes.
作者信息
Van Belle T L, Taylor P, von Herrath M G
机构信息
Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
出版信息
Drug Discov Today Dis Models. 2009 Summer;6(2):41-45. doi: 10.1016/j.ddmod.2009.03.008.
Abstract
Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researchers to zoom in on specific aspects of this complex disease. In this review, we provide an overview of currently available mouse models for T1D.
摘要
20世纪70年代末和80年代初1型糖尿病（T1D）动物模型的发现推动了我们对T1D遗传学、病因学和发病机制的理解，尤其是非肥胖糖尿病（NOD）小鼠。从那时起，转基因和基因靶向技术使得能够产生许多遗传和致病复杂性降低的模型。这些模型使研究人员能够聚焦于这种复杂疾病的特定方面。在本综述中，我们概述了目前可用的T1D小鼠模型。
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