社会支持在孤独感与人类疱疹病毒6型（HHV - 6）抗体滴度之间起中介作用。
Social Support Mediates Loneliness and Human Herpesvirus Type 6 (HHV-6) Antibody Titers.
作者信息
Dixon Denise, Cruess Stacy, Kilbourn Kristin, Klimas Nancy, Fletcher Mary Ann, Ironson Gail, Baum Andrew, Schneiderman Neil, Antoni Michael H
机构信息
University of Miami.
出版信息
J Appl Soc Psychol. 2006 Jul 31;31(6):1111-1132. doi: 10.1111/j.1559-1816.2001.tb02665.x.
Abstract
The current study investigated the impact of a severe environmental stressor and the role that declining social integration played in mediating its effect on loneliness and immune status. Increased loneliness and decreased social support in the months following the stressor (storm) were significantly associated with increased HHV-6 antibody titers, reflecting poorer control over the virus. Poorer social integration mediated the relationship between loneliness and HHV-6, even after controlling for nonspecific polyclonal B-cell activation, disease status (CD3+CD4+ cell counts), living arrangements, acute social losses (bereavement), and potential disruptions in social-support resources. These findings suggest that specific elements of social support may explain the oft-noted negative effects of loneliness on the immune system, and generalized to a medically vulnerable population.
摘要
当前的研究调查了一种严重环境应激源的影响，以及社会融合度下降在介导其对孤独感和免疫状态影响方面所起的作用。应激源（风暴）过后的几个月里，孤独感增加和社会支持减少与人类疱疹病毒6型（HHV-6）抗体滴度升高显著相关，这反映出对该病毒的控制较差。即使在控制了非特异性多克隆B细胞激活、疾病状态（CD3+CD4+细胞计数）、生活安排、急性社会损失（丧亲之痛）以及社会支持资源的潜在中断等因素之后，较差的社会融合度仍介导了孤独感与HHV-6之间的关系。这些发现表明，社会支持的特定要素可能解释了孤独感对免疫系统常见的负面影响，并且这一结论可推广至医学上易受影响人群。
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