血清素的作用以及血清素相关基因与酒精脱氢酶和乙醛脱氢酶基因在酒精依赖中的可能相互作用——综述
The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review.
作者信息
Huang Charles Lung-Cheng
出版信息
Am J Transl Res. 2010 Mar 25;2(2):190-9.
Abstract
Alcohol dependence is believed to be a multifactorial, polygenic disorder involving complex gene-gene and gene-environment interactions and confounded by heterogeneity and sociocultural factors. Serotonin (5-Hydroxytryptamine, 5-HT) is thought to be involved in many aspects of alcohol consumption, abuse, and dependence. There was some evidence that serotonin-related genes might interact with the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol dependence. In the current review, we discuss the role of serotonin and possible interaction of serotonin-related genes with ADH and ALDH genes in alcohol dependence.
摘要
酒精依赖被认为是一种多因素、多基因的疾病，涉及复杂的基因-基因和基因-环境相互作用，并受到异质性和社会文化因素的影响。血清素（5-羟色胺，5-HT）被认为参与了饮酒、酗酒和依赖的多个方面。有证据表明，血清素相关基因可能在酒精依赖的发生发展中与乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）基因相互作用。在本综述中，我们讨论了血清素的作用以及血清素相关基因与ADH和ALDH基因在酒精依赖中可能的相互作用。
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