Gautam Naveen, Ajmera Neha, Gupta Shikha, Gautam D C
Department of Chemistry, L.B.S. Govt. P.G. College, Kotputli, Jaipur, India.
Nucleosides Nucleotides Nucleic Acids. 2010 Mar;29(3):178-89. doi: 10.1080/15257771003708538.
This article describes the synthesis of new substituted 10 H-phenothiazines by Smiles rearrangement. These compounds are then used as a base to form ribofuranosides by treating them with a sugar (1-O-acetyl-2,3,5-tri-O-benzoyl-beta-ribofuranose). On oxidation with hydrogen peroxide in glacial acetic acid, these phenothiazines yield their sulfones. These compounds are screened for antioxidant and antimicrobial activity and their structure has been established by elemental analysis and spectroscopic data.
本文描述了通过斯迈尔斯重排反应合成新型取代的10H-吩噻嗪。然后将这些化合物用作碱，通过与一种糖（1-O-乙酰基-2,3,5-三-O-苯甲酰基-β-D-呋喃核糖）反应形成呋喃核糖苷。在冰醋酸中用过氧化氢氧化这些吩噻嗪，可得到它们的砜。对这些化合物进行了抗氧化和抗菌活性筛选，并通过元素分析和光谱数据确定了它们的结构。
