人体中的胆固醇代谢
Cholesterol metabolism in man.
作者信息
Grundy S M
出版信息
West J Med. 1978 Jan;128(1):13-25.
Abstract
Recent investigations on cholesterol metabolism in man have led to new insights into diseases associated with abnormal accumulations of cholesterol in plasma (hypercholesterolemia), arterial tissues (atherosclerosis) and biliary tract (gallstones). Regulation of cholesterol synthesis under the influence of dietary and plasma cholesterol, may play a crucial role in determining biliary and tissue concentrations of this sterol. Plasma concentrations, on the other hand, appear to be controlled by complex mechanisms for secretion, transformation and removal of plasma lipoproteins. The recent identification of specific cellular receptors for uptake of plasma lipoproteins represents a significant advance for the understanding of regulation of both plasma and tissue concentrations, and possibly of the basic mechanisms underlying accumulation of cholesterol in atherosclerotic plaques.
摘要
近期对人体胆固醇代谢的研究，为与血浆（高胆固醇血症）、动脉组织（动脉粥样硬化）和胆道（胆结石）中胆固醇异常积聚相关的疾病带来了新的见解。在饮食和血浆胆固醇的影响下，胆固醇合成的调节可能在决定这种固醇的胆汁和组织浓度方面发挥关键作用。另一方面，血浆浓度似乎受血浆脂蛋白分泌、转化和清除的复杂机制控制。最近发现了用于摄取血浆脂蛋白的特定细胞受体，这对于理解血浆和组织浓度的调节，以及可能对于动脉粥样硬化斑块中胆固醇积聚的基本机制而言，是一项重大进展。
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