Department of Surgery, Niigata Prefectural Central Hospital, 205 Shinnan-Cho, Joetsu, Niigata, Japan.
Breast Cancer. 2013 Jul;20(3):271-4. doi: 10.1007/s12282-010-0205-x. Epub 2010 Apr 22.
We report here a quite rare case of ductal carcinoma in situ (DCIS) with isolated tumor cells in the sentinel lymph node in a 17-year-old adolescent girl whose mother also had advanced breast cancer. Findings included an elastic mass in the right breast accompanied by serous nipple discharge. DCIS of the breast was diagnosed following core needle biopsy. Although no invasive focus was clearly observed in the mastectomy sample, isolated tumor cells were found in the sentinel lymph node. Although the family refused genetic testing, a hereditary abnormality may have played a role in the carcinogenesis in this case.
我们在此报告一例非常罕见的病例，一名 17 岁的青少年女孩患有导管原位癌（DCIS），前哨淋巴结中存在孤立肿瘤细胞，其母亲也患有晚期乳腺癌。该患者的表现为右侧乳房有弹性肿块，伴有浆液性乳头溢液。乳腺核心针活检诊断为 DCIS。虽然在乳房切除术标本中未明显观察到浸润性病灶，但在前哨淋巴结中发现了孤立肿瘤细胞。尽管该家族拒绝进行基因检测，但遗传异常可能在该病例的癌变中发挥了作用。
