Janzen H, Ludwig B, Lycko E, Gerlach D
Z Rechtsmed. 1978 Jan 31;80(4):305-9. doi: 10.1007/BF02092328.
Toxic lesions were found in liver, kidney and brain of rats and rabbits after oral application of hashish for 7 or 30 days. The brain tissue showed hyperemia and edema. The cerebral cortex, brain stem and cerebellum contained ganglion cells with eccentric nuclei and an icreased number of nucleoli. Different stages of cell lesions could be distinguished by nuclear vacuoles, pyknosis and karyolysis. The cytoplasma was loosened and showed numerous vacuoles. In the kidney we found, besides interstitial hemorrhage, cloudy swelling of the proximal tubules with vacuolous degeneration and nuclear pyknosis and karyolysis in all stages. The glomeruli were often enlarged with thickening of Bowman's capsule and surrounding cellular infiltration with cell fragments. The liver cells showed irregularities of nuclei and vacuolated nuclei, plasma vacuoles and cell necrosis. Infiltrations of round cells at the portal-biliary areas were usually combined with an activation of the Kupffer cells and intracellular bile stasis.
给大鼠和兔子口服大麻7天或30天后，在其肝脏、肾脏和大脑中发现了毒性损伤。脑组织出现充血和水肿。大脑皮层、脑干和小脑中的神经节细胞出现核偏心和核仁数量增加。细胞核空泡、固缩和溶解可区分细胞损伤的不同阶段。细胞质疏松，出现大量空泡。在肾脏中，除了间质出血外，近端小管出现混浊肿胀，伴有空泡变性以及各个阶段的核固缩和核溶解。肾小球常肿大，鲍曼囊增厚，周围有细胞碎片的细胞浸润。肝细胞出现核不规则和核空泡化、质膜空泡和细胞坏死。门脉-胆管区域的圆形细胞浸润通常伴有库普弗细胞活化和细胞内胆汁淤积。
