Department of Anatomic Pathology, Cleveland Clinic, Section of Neuropathology, Cleveland, Ohio 44195, USA.
Am J Surg Pathol. 2010 May;34(5):e1-13. doi: 10.1097/PAS.0b013e3181d9ba38.
For patients with pharmacoresistent epilepsy, surgical excision is often an effective means of controlling and sometimes curing the seizures. Excised tissue frequently provides information regarding the precise etiology of the epilepsy. This review examines some of the more commonly encountered pathologies encountered in the neuropathology arena in this clinical venue. The most common identifiable causes of chronic epilepsy including low-grade tumors, hippocampal sclerosis, malformation of cortical development (cortical dysplasia), and remote infarcts will be discussed. Differential diagnostic difficulties will be examined.
对于药物难治性癫痫患者，手术切除通常是控制甚至治愈癫痫发作的有效手段。切除的组织通常能提供有关癫痫确切病因的信息。本文回顾了神经病理学领域在该临床环境中遇到的一些更常见的病变。将讨论包括低级别肿瘤、海马硬化、皮质发育畸形（皮质发育不良）和陈旧性梗死等常见的慢性癫痫病因。还将探讨鉴别诊断的难点。
