Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
Org Biomol Chem. 2010 Jun 21;8(12):2735-48. doi: 10.1039/c002479a. Epub 2010 Apr 23.
2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and sulfoxide levels of oxidation are rationalised on the basis of the nature of the substituents.
2-硫代-3-氯丙烯酰胺与重氮烷烃发生 1,3-偶极环加成反应，生成一系列新型吡唑啉和吡唑。基于取代基的性质，对 2-硫代-3-氯丙烯酰胺的硫化物和亚砜氧化水平的环加成反应的机理和合成特征进行了合理化。
