Das Jayanta Kr, Sengupta Sujata, Mitra Subhabrata, Gangopadhyay Asok Kr
Department of Dermatology, VIMS, Ramakrishna Mission Seva Pratisthan, 99, Sarat Bose Road, Kolkata - 700 026, India.
Indian J Dermatol. 2010;55(1):109-12. doi: 10.4103/0019-5154.60367.
Tuberculides, the supposedly immunologic reactions to the products of dead Mycobacterium tuberculosis bacilli deposited in the skin from distant foci of tubercular infection, are presently considered to be of two types-papulonecrotic tuberculide and lichen scrofulosorum. Simultaneous occurrence of both the types in the same patient is very rare. We report the case of an adult male without any known internal tubercular focus who showed two types of skin lesions, clinically typical and histopathologically consistent with the diagnoses of papulonecrotic tuberculide and lichen scrofulosorum, occurring simultaneously. Polymerase chain reaction showed the presence of Mycobacterium tuberculosis DNA in papulonecrotic tuberculide type of lesion, and both types of lesions responded promptly to anti-tubercular drugs.
结核疹是对远处结核感染灶中沉积在皮肤的死结核分枝杆菌产物的一种推测性免疫反应,目前被认为有两种类型——丘疹坏死性结核疹和瘰疬性苔藓。同一患者同时出现这两种类型的情况非常罕见。我们报告一例成年男性病例,该患者无任何已知的体内结核病灶,却同时出现了两种皮肤病变,临床典型且组织病理学符合丘疹坏死性结核疹和瘰疬性苔藓的诊断。聚合酶链反应显示在丘疹坏死性结核疹型病变中存在结核分枝杆菌DNA,且两种病变对抗结核药物均迅速产生反应。